Vortragstitel - Reof Chemicals in Biomedical Terminologies, Stefan Schulz Medical Informatics Research Group Center Freiburg

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  • 1.Representation of Chemicals in Biomedical Terminologies Stefan Schulz Medical Informatics Research Group UniversityMedical Center Freiburg, Germany 2nd CHEBI User Group Workshop 201023-24 June 2010EMBL-EBI, Hinxton, Cambridge, CB10 1SD, UK
  • 2.Purpose of this talk To give an overview of sources of chemicals in biomedical terminologies based on the UMLS To estimate their coverage related to ChEBI To analyze the ontological representation in the sources To discuss cross mapping with ChEBI
  • 3.Overview of UMLS
  • 4.Unified Medical Language System (UMLS) Metathesaurus Very large, multi-purpose and multi-lingual vocabulary database (158 sources) information about biomedical concepts (2M), their various names (8M), and relationships among them (41M) IP restrictions apply Semantic Network Semantic Types, that provide a consistent categorization of all concepts represented in the UMLS Metathesaurus
  • 5.C0000275|GER|P|L1226318|PF|S1468264|2-Chloradenosin|3| C0000275|GER|s|L8592208|PF|S10685969|CHLORADENOSIN 02|3| C0000275|ITA|P|L2136500|PF|S2474722|2-Cloroadenosina|3| C0000275|POR|P|L3290657|PF|S3818161|2-Cloroadenosina|3| C0000275|SPA|P|L3379000|PF|S3906504|2-Cloroadenosina|3| C0000275|SWE|P|L3419094|PF|S3946595|2-kloradenosin|3| C0000287|CZE|P|L6770587|PF|S7862131|2-hydroxy-5-nitrobenzylbromid|3| C0000287|ENG|P|L0000287|PF|S0008061|2-Hydroxy-5-nitrobenzyl Bromide|0| C0000287|ENG|P|L0000287|VO|S0007885|2 Hydroxy 5 nitrobenzyl Bromide|0| C0000287|ENG|S|L0022780|PF|S0055692|Koshland's Reagent I|0| C0000287|ENG|S|L0022780|VO|S0055691|Koshland Reagent I|0| C0000287|ENG|S|L0022780|VO|S0055694|Koshlands Reagent I|0| C0000287|ENG|S|L0022780|VW|S0080181|Reagent I, Koshland's|0| C0000287|ENG|S|L0309506|PF|S0055693|Koshlands Reagent|0| C0000287|ENG|S|L0309506|VO|S0055690|Koshland Reagent|0| C0000287|ENG|S|L0309506|VO|S0080187|Reagent, Koshland|0| C0000287|ENG|S|L0309506|VW|S0080188|Reagent, Koshlands|0| C0000287|ENG|S|L0359802|PF|S0504134|Phenol, 2-(bromomethyl)-4-nitro-|0| C0000287|ENG|S|L7671184|PF|S8865410|2-Hydroxy-5-nitrobenzyl Bromide [Chemical/Ingredient]|1| C0000287|ENG|s|L6520804|PF|S7598104|KOSHLANDS REAGENT 01|0| C0000287|ENG|s|L6524599|PF|S7596787|HYDROXYNITROBENZYL BROMIDE 02 05|0| C0000287|FIN|P|L1507134|PF|S1803043|2-hydroksi-5-nitrobentsyylibromidi|3| C0000287|FRE|P|L3249939|PF|S3777562|Bromure 2-hydroxy-5-nitrobenzyl|3| C0000287|FRE|S|L3245113|PF|S3772614|2-hydroxy-5-nitrobenzyl, bromure|3| C0000287|GER|P|L1226332|PF|S1468278|2-Hydroxy-5-Nitrobenzylbromid|3| C0000287|GER|S|L1787712|PF|S2084853|Koshland-Reagens I|3| C0000287|GER|s|L8590862|PF|S10687072|HYDROXYNITROBENZYLBROMID 02 05|3| C0000287|GER|s|L8590903|PF|S10687407|KOSHLAND REAGENS 01|3| C0000287|ITA|P|L2136502|PF|S2474724|2-Idrossi-5-nitrobenzil bromuro|3| C0000287|POR|P|L3290666|PF|S3818171|2-Hidroxi-5-nitrobenzil Brometo|3| C0000287|POR|S|L3324426|PF|S3852791|Reagente de Koshland I|3| C0000287|SPA|P|L3379007|PF|S3906512|2-Hidroxi-5-nitrobencil Bromuro|3| C0000287|SPA|S|L3410013|PF|S3937780|Reactivo de Koshland I|3| C0000287|SWE|P|L3419091|PF|S3946592|2-hydroxi-5-nitrobensylbromid|3| C0000289|CZE|P|L6766518|PF|S7862132|2-hydroxyfenethylamin|3| C0000289|ENG|P|L0000289|PF|S0008063|2-Hydroxyphenethylamine|0| C0000289|ENG|P|L0000289|VO|S0007886|2 Hydroxyphenethylamine|0| UMLS terms and concepts Cross-source and language term mapping to CUIs done by NLM
  • 6.UMLS relations C0000726|CHD|C0041638||MSHSPA|MSHSPA|| C0000726|CHD|C0041638||MSHSWE|MSHSWE|| C0000726|CHD|C0041638||MSH|MSH|| C0000726|CHD|C0041638||SNMI|SNMI|| C0000726|CHD|C0151653||CST|CST|| C0000726|CHD|C0151705||CST|CST|| C0000726|CHD|C0225222|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0225222|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0225222||RCD|RCD|| C0000726|CHD|C0226727|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0226727|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0227345|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0227345|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0227613|part_of|UWDA|UWDA|| C0000726|CHD|C0227614|part_of|UWDA|UWDA|| C0000726|CHD|C0227667|part_of|UWDA|UWDA|| C0000726|CHD|C0227668|part_of|UWDA|UWDA|| C0000726|CHD|C0228904|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0228904|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0228905|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0228905|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0230165||SNMI|SNMI|| C0000726|CHD|C0230166|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0230166|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0230166||SNMI|SNMI|| C0000726|CHD|C0230167||SNMI|SNMI|| C0000726|CHD|C0230168|isa|SCTSPA|SCTSPA|| C0000726|CHD|C0230168|isa|SNOMEDCT|SNOMEDCT|| C0000726|CHD|C0230168|part_of|UWDA|UWDA|| C0000726|CHD|C0230168||RCD|RCD|| Relations preserved from their sources Thesaurus style relations (CHD / PAR) More precise relations (relationship attribute) i.e. part-of, is-a
  • 7.UMLS Semantic Network
  • 8.UMLS Semantic Network Chemicals in the UMLS SN
  • 9.Semantic Labeling of UMLS concepts Semantic labeling Done by the NLM Each UMLS concept is assigned to one or more semantic types
  • 10.Chemicals in UMLS and its sources
  • 11.Semantic Network types for chemicals: T103|Chemical T104|Chemical Viewed Structurally T109|Organic Chemical T110|Steroid T111|Eicosanoid T114|Nucleic Acid, Nucleoside, or Nucleotide T115|Organophosphorus Compound T116|Amino Acid, Peptide, or Protein T118|Carbohydrate T119|Lipid T120|Chemical Viewed Functionally T121|Pharmacologic Substance T122|Biomedical or Dental Material T123|Biologically Active Substance T124|Neuroreactive Substance or Biogenic Amine T125|Hormone T126|Enzyme T195|Antibiotic T192|Receptor T127|Vitamin T129|Immunologic Factor T130|Indicator, Reagent, or Diagnostic Aid T131|Hazardous or Poisonous Substance T196|Element, Ion, or Isotope T197|Inorganic Chemical T200|Clinical Drug
  • 12.Chemicals in UMLS source vocabularies
  • 13.Medical Subject Headings (MeSH) MSH 2,4,6-TIP MSH hurin protein, Hura crepitans MSH norfentanyl monohydrochloride MSH Phenylglyoxal MSH gas vesicle structural protein A, Bacteria MSH yttrium silicate MSH 2-aminoethanethiosulfuric acid, 35S-labeled MSH acethropan-S, acetate MSH N-methyl-alpha-tocopheramine nitroxide MSH antimony pentachloride MSH ISG20 protein, human MSH medosulepine, (Z)-isomer MSH MUC1 protein, human MSH valacyclovir, x-hydrochloride, (D)-isomer MSH Fmn1 protein, mouse MSH cytochrome c, N-epsilon-acetimidate MSH 14,16-dianhydrogi-toxigenin-3-O-xylopyranosyl-1-2-O-galactopyranoside MSH 4-iodoclonidine MSH poly(ethylenimine sulfide) MSH 2-methoxy-6-tridecyl-1,4-benzoquinone MSH Lisuride MSH Man-(1-3)-(Man-(1-6))-Man MSH Sre1 protein, S pombe MSH slou protein, Drosophila MSH Ac-odv-e56 protein, Autographa californica nucleopolyhedrovirus MSH YoYo-3 MSH cripowellin B MSH 3-quinuclidinyl atrolactate, (S-(R*,S*))-isomer MSH 4-vinyl-N-carboxymethylpyridinium MSH 2,5-dihydroxybenzylidene aminoguanidine MSH purealidin S
  • 14.SNOMED Clinical Terms SNOMEDCT bisalbumins SNOMEDCT Spiramycin Adipate SNOMEDCT 2,2,2-trichloroethanol SNOMEDCT Promethazine Hydrochloride SNOMEDCT thenium closylate SNOMEDCT CD67 Antigen SNOMEDCT Ethyleneimine antineoplastic SNOMEDCT hydrocortisone acetate and neomycin sulfate SNOMEDCT Hexan-2,5-dione SNOMEDCT Steroidal neuromuscular blocker SNOMEDCT trospium chloride SNOMEDCT Neostigmine Methylsulfate SNOMEDCT Oligotriacrylate 480 SNOMEDCT Lemon specific immunoglobulin E SNOMEDCT Monocarboxylate SNOMEDCT Ethosuximide SNOMEDCT Phthalic acid ester SNOMEDCT Combination ulcer healing drugs SNOMEDCT darunavir SNOMEDCT Ophthalmic form clotrimazole SNOMEDCT Blood group antigen Horn SNOMEDCT Mycoplasma synoviae bacterin SNOMEDCT Dimethoxanate SNOMEDCT Demeton SNOMEDCT Silicon Dioxide SNOMEDCT ^133^Iodine SNOMEDCT Amylose SNOMEDCT glymidine SNOMEDCT Parsley specific immunoglobulin E SNOMEDCT Anhydrous borate SNOMEDCT Tetracycline
  • 15.LOINC LNC Manihot esculenta crantz Antibody.immunoglobulin E LNC Glutamine |; urine LNC Chlamydia trachomatis D+E+F+G+H+I+J+K IgA |; Bld-Ser-Plas LNC HLA-D w16 |; bld-ser-plas LNC Colorado tick fever virus Ab |; bld-ser-plas LNC Fluconazole |; isolate & serum LNC African horse sickness virus Antigen LNC Zea mays Ab LNC Le^b Antibody LNC Triglyceride |; Semen LNC Leishmania tropica Antibody.immunoglobulin G LNC Cystine |; White blood cells LNC annexin A5 LNC Artemisia douglasiana Antibody.immunoglobulin E LNC 2,4,5-trichlorophenoxyacetate |; bld-ser-plas LNC Streptococcus pneumoniae 9 IgG |; bld-ser-plas LNC 2-hydroxyglutarate |; urine LNC Dodecenoylcarnitine (C12:1) |; Cerebral spinal fluid LNC Toxocara canis Ab |; cerebral spinal fluid LNC Globulin |; bld-ser-plas LNC Streptococcus species antibody LNC BSA (Bovine serum albumin) |; White blood cells LNC Threonine/Creatinine LNC Amylases LNC Streptococcus pneumoniae 9n Antibody.immunoglobulin G LNC Mycoplasma pneumoniae Ab |; body fluid LNC Amobarbital |; gastric fluid LNC Mycoplasma pneumoniae Antibody.immunoglobulin G LNC Haemophilus influenzae B LNC Insulin-Like Growth-Factor-Binding Proteins
  • 16.Product Category Thesaurus UMD Reagents, Serology, Virus, Retrovirus, HIV-1, Antibody UMD Reagents, Molecular Assay, Tumor Marker, Chromosome, Translocation, t(12;15) UMD Reagents, Microbiology, Bacteria, Identification, Listeria monocytogenes UMD Reagents, Molecular Assay, Infection, Bacteria, Bordetella Species UMD Reagents, Molecular Assay, Infection, Virus, Epstein-Barr, DNA UMD B Loci Human Leukocyte Antigen Determination Reagents UMD Cell Culture Media, Serum UMD Trench Fever Diagnostic Reagents UMD Reagents, Serology, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-I/II UMD Clostridium botulinum Identification/Detection Reagents UMD Reagents, Molecular Assay, Infection, Virus, Eastern Equine Encephalitis, RNA UMD Reagents, Hematology, Standard, Coagulation, Plasma UMD Reagents, Immunohematology, Antibody Detection/Identification, Enhancement Media, Polyethylene Glycol UMD Listeria monocytogenes Detection/Identification Reagents UMD Reagents, Molecular Assay, Infection, Virus, Hepatitis G UMD Reagents, Immunoassay, Toxicology, Salicylate UMD Reagents, Immunoassay, Control, Bone Metabolism UMD Alpha2-Antiplasmin Determination Reagents UMD Pyridoline Crosslink Determination Reagents UMD Activated Partial Thromboplastin Time (APTT) Determination Reagents UMD Reagents, Hematology, Fibrinolysis, Plasminogen Activator, Urokinase UMD Tuberculosis Diagnostic Reagents UMD Reagents, Immunoassay, Tumor Marker, Enzyme, Neuron Specific Enolase UMD Reagents, Immunoassay, Tumor Marker, Fecal Occult Blood UMD CLEANSER UMD Reagents, Molecular Assay, Infection, Bacteria, Ehrlichia Species UMD Central Nervous System Drug Level Determination Reagents, Anticonvulsant Agent UMD Sinusitis Diagnostic Reagents UMD Anti-Filaggrin Antibody Determination Reagents UMD Kappa Reagents, Light Chain Monoclonal Immunoglobulin UMD Reagents, Molecular Assay, Infection, Virus, Eastern Equine Encephalitis
  • 17.Master Drug Database MDDB Deoxyribose (Bulk) Powder MDDB Lithium Chloride (Bulk) Powder MDDB Mercurous Chloride (Bulk) Powder MDDB Ferric Chloride (Bulk) Powder MDDB Ginger Oil (Bulk) MDDB Levodopa Powder MDDB Antimony Trichloride (Bulk) Powder MDDB Calcium Lactate Powder MDDB Danthron Powder MDDB Vitamin E Acetate (Bulk) Liquid MDDB Niacin Powder MDDB Betamethasone Acetate (Bulk) Powder MDDB Dill Seed Oil MDDB Emollient Cream MDDB Dye FDC Blue 1 (Brilliant Blue FCF) - Powder MDDB Corticotropin (Bulk) Powder MDDB Xylometazoline HCl (Bulk) Powder MDDB Dentifrices - Solution MDDB Orphenadrine Citrate Powder MDDB Blood Glucose Calibration - Liquid - Low MDDB Xanthan Gum Powder MDDB L-Alpha Pinene (Bulk) Powder MDDB lavender oil MDDB juniper tar MDDB Rice Bran (Bulk) Oil MDDB Bay Oil (Myrcia Oil) MDDB Tamoxifen Citrate (Bulk) Powder MDDB Eucalyptol (Bulk) Liquid MDDB Hyoscyamine Sulfate Powder MDDB Triclosan (Bulk) Powder MDDB Lanolin Oil-Urea (Bulk) Oint MDDB Chlortetracycline HCl Powder
  • 18.RxNORM RXNORM Phenazopyridine HCl Powder RXNORM Pri-Methylate RXNORM Perdiem RXNORM Chewing Gum, dose form RXNORM Xylocaine-MPF-Epinephrine RXNORM Robitussin-DM RXNORM proxymetacaine RXNORM Petroleum distillate RXNORM Miradon RXNORM Ciproflaxacin RXNORM PerioChip RXNORM Oral Strip RXNORM Rectal Ointment RXNORM Octocaine with Epinephrine RXNORM Hydro Pro D RXNORM Dynacirc RXNORM Hydrophene DH RXNORM Paloxin RXNORM Levsin/SL Tablets RXNORM Glutarol RXNORM Benzaclin RXNORM Diethylstilbestrol RXNORM AMINOSALICYLATE RXNORM CEFACLOR MISCELL POWDER (GM) RXNORM Chlorpromazine HCl Powder RXNORM L-All 12 RXNORM Therapy Bayer RXNORM Bellamine S RXNORM Lavacol RXNORM Auro Ear
  • 19.Multum MediSource Lexicon MMSL Vitamins MMSL Gen-Cyclobenzaprine MMSL Uni-Tussin DM MMSL Afrin Pump Mist MMSL Meperidine+promethazine MMSL Lipidil Supra MMSL Icy Hot PM MMSL Rocuronium MMSL Gormel MMSL DHT brand of dihydrotachyesterol MMSL Schuessler's Acne Remedy MMSL AlphaBath MMSL Dymadon P MMSL Rynesa 12S MMSL Mersol MMSL doxycycline topical MMSL Calcium Sulfate, Anhydrous MMSL PSE Allergy MMSL Z-Cof DM MMSL Ramses Personal MMSL Tri-Hist Pediatric MMSL Cortisone Acetate Micronized, compounding powder MMSL Micrainin MMSL Ceron Drops MMSL Vasotec MMSL epinephrine compounding powder MMSL Benoquin MMSL Spastrin MMSL Tramal SR MMSL Antiseptic Skin Cleanser
  • 20.Alternative Billing Concepts ALT Matthiola graeca / giliflower ALT Adoxa moschatellina / common moschatel ALT Cinnamomum camphora, camphor, Homeopathic preparation ALT Croton eleuteria / cascarilla / amber kabug / sweet bark ALT Pediculus capitis, Homeopathic preparation ALT Zea italica, corn silk, Homeopathic preparations ALT Hippozaeninum / glanders nosode ALT Cobalt ALT Salvia officinalis, homeopathic preparation ALT Arbutus andrachne preparation ALT Andira araroba / chrysarobinum / chrysophan / goa powder ALT Sedum acre / small houseleek ALT Urinum humanum / human urine ALT Aurum muriaticum natronatum / double chloride of gold and sodium / sodium chloroaurate ALT Cistus canadensis preparation ALT Xanthorrhea arborea preparation ALT Cornus florida preparation ALT Aquilegia vulgaris preparation ALT Ergotinum, homeopathic preparation ALT Mimulus lewisii / rose colored musk ALT Lac vaccinum coagulatum / milk curds ALT Robinia pseudoacacia / yellow locust ALT Solidago virgaurea, homeopathic preparation ALT Cholesterinum / cholesterine ALT Benzinum dinitricum, benzinum, benzol, coal naphtha, Homeopathic preparation ALT Derris pinnata / pongram ALT Calcarea renalis, Homeopathic preparations ALT Centella asiatica, homeopathic preparation ALT Culex musca, Homeopathic preparation ALT Python regia (homeopathic remedy) ALT Darlingtonia californica / California pitcher plant ALT Five flower formula / rescue remedy
  • 21.Chemicals in UMLS source vocabularies
  • 22.Hidden references to chemicals Accidental poisoning by other opiates NOS Accidental poisoning by codeine Accidental poisoning by pethidine Accidental poisoning by morphine Accidental poisoning by opium Accidental poisoning by aromatic analgesics NOS Accidental poisoning by aromatic analgesics NEC Accidental poisoning by acetanilide Accidental poisoning by phenacetin Accidental poisoning by aminophenazone Accidental poisoning by antirheumatics NOS Accidental poisoning by pentazocine Accidental poisoning by pentobarbitone Accidental poisoning by quinalbarbitone Accidental poisoning by bromides Accidental poisoning by cabromal derivatives Accidental poisoning by carbamic esters Accidental poisoning by chlorpromazine Accidental poisoning by fluphenazine Accidental poisoning by prochlorperazine Accidental poisoning by promazine Accidental poisoning by spiperone Accidental poisoning by chlordiazepoxide Example: ICD9-CM Example: *intox* or “*poison* or *allerg* returns 10800 non-chemical concepts roughly half of them refer to chemicals
  • 23.Explicit reference to chemicals
  • 24.Chemicals in UMLS: Summary MeSH (85% Substance terms) is the most important source for chemicals Health care related sources include also natural products, drugs, lab procedures Pharmacy related sources include pharmaceutical preparations and products Many sources are rather heterogeneous (UMLS typing not always consistent) (implizit) reference to chemicals in most clinical terminologies
  • 25.Ontology aspects of UMLS chemistry sources
  • 26.Ontology aspects of UMLS chemistry sources UMLS only includes Concept – Relation – Concept triplets Only very few UMLS sources are “ontology-like”, i.e. they have some formal semantics, e.g. SNOMED CT or  NDF-RT UMLS distinguishes thesaurus-style broader/narrower hierarchy-building relations from more precise ones (“relation attributes”) Only part of the latter describe the entities to be represented themselves (e.g. part-of, has-active ingredient), other ones describe the representational units and the attached terms (“mapped-to”, “has-translation”)
  • 27.Ontological relations involving chemicals (608,315) Chemical – Rel – Non-Chemical
  • 28.Ontological relations between chemicals (173,502) Chemical – Rel – Chemical
  • 29.Analysis of relations in UMLS Broad spectrum and high number of relations between chemicals and non-chemicals. Of interest for relating chemical with other concepts of biomedical interest. Rather poor in terms of inter-chemical relations, often due to Semantic type misassignments SNOMED CT: quinupristin-dalfopristin has_active_ingredient dalfopristin NDFFT: Raloxifene Hydrochloride has_mechanism_of_action Selective Estrogen Receptor Modulators CRISP: Reserpine used_for reserpate derivative NCI: Rimantadine Hydrochloride has_free_acid_or_base_form Rimantadine
  • 30.MeSH in PubChem Properties as parents in informal hierarchy
  • 31.Mapping / Tagging
  • 32.UMLS MetaMap / Medical Text Indexer 567 Morphinans [Organic Chemical] 577 Seconal [Organic Chemical,Pharmacologic Substance] 604 Talwin [Organic Chemical,Pharmacologic Substance] 627 Acetanilides [Organic Chemical,Pharmacologic Substance] 637 Aromatic (AROMATICS) [Organic Chemical,Pharmacologic Substance] 645 Esters [Organic Chemical] 645 derivatives [Chemical Viewed Structurally] 660 Acetanilid (acetanilide) [Organic Chemical,Pharmacologic Substance] 660 Amidophenazon (Aminopyrine) [Organic Chemical,Pharmacologic Substance] 660 Bromides [Inorganic Chemical] 660 Chlorpromazine [Organic Chemical,Pharmacologic Substance] 660 Codeine [Organic Chemical,Pharmacologic Substance] 660 Morphine [Organic Chemical,Pharmacologic Substance] 660 Opium [Organic Chemical,Pharmacologic Substance] 660 Pentazocine [Organic Chemical,Pharmacologic Substance] 660 Pentobarbitone (Pentobarbital) [Organic Chemical,Pharmacologic Substance] 660 Pethidine (Meperidine) [Organic Chemical,Pharmacologic Substance] 660 Phenacetin [Organic Chemical,Pharmacologic Substance] 660 Quinalbarbitone (Secobarbital) [Organic Chemical,Pharmacologic Substance] 1000 Fluphenazine [Organic Chemical,Pharmacologic Substance] MetaMap Version Used: metamap09 MetaMap Options: -A+ Lexicon Used: 2009 Knowledge Source Used: 09 Input Text: Accidental poisoning by codeine Accidental poisoning by pethidine Accidental poisoning by morphine Accidental poisoning by opium Accidental poisoning by aromatic analgesics NOS Accidental poisoning by aromatic analgesics NEC Accidental poisoning by acetanilide Accidental poisoning by phenacetin Accidental poisoning by aminophenazone Accidental poisoning by antirheumatics NOS Accidental poisoning by pentazocine Accidental poisoning by pentobarbitone Accidental poisoning by quinalbarbitone Accidental poisoning by bromides Accidental poisoning by cabromal derivatives Accidental poisoning by carbamic esters Accidental poisoning by chlorpromazine Accidental poisoning by fluphenazine
  • 33.Whatizit
  • 34.Conclusions Most Biomedical Terminologies contain chemical concepts, drugs or concepts referring to them MeSH has the highest coverage Fairly good coverage of semantic relations linking chemicals to non-chemicals No significant source for semantic relations between chemicals Mappings ChEBI – UMLS: to MeSH via PubChem, but only higher level MeSH terms NLP tools (MetaMap, Medical Text Indexer, WhatIzIt) not yet optimized for Chemical names.
  • 35.Veterans Health Administration National Drug File VANDF WHEAT DEXTRIN VANDF ALOE/BENZOCAINE/LANOLIN/MENTHOL VANDF benazepril VANDF COLOR,ARTIFICIAL VANDF Acacia Extract VANDF Secobarbital sodium VANDF Cilastatin Sodium VANDF POLYTHIAZIDE/PRAZOSIN VANDF CARDIOVASCULAR AGENTS,OTHER VANDF Doxazosin VANDF Phenylephrine + promethazine + codeine VANDF SODIUM XYLENESULFONATE VANDF Potassium VANDF ALLERGENIC EXTRACT, PENICILLIUM NOTATUM VANDF LOXILAN VANDF Fosfomycin VANDF CEPHALOSPORIN 2ND GENERATION VANDF ALLERGENIC EXTRACT, TREE, MAPLE MIX VANDF CALCIUM IODATE VANDF Antiemetics VANDF DYE EVANS BLUE VANDF ACETAMINOPHEN/DEXTROMETHORPHAN/GUAIFENESIN/PSEUDOEPHEDRINE VANDF ALLERGENIC EXTRACT, JUNE POLLEN VANDF DUODERM HYDROGEL C#1879-87 VANDF Equine diphtheria antitoxin VANDF Loxipine Succinate VANDF WOOL WAX ALCOHOL
  • 36.CRISP Thesaurus SAB CUIStr CSP Tetrabenazine CSP gamma-Aminobutyrate CSP methoxyindole CSP Yellow Fever Vaccine CSP Clomiphene CSP Chenodeoxycholate CSP Crack Cocaine CSP H antigen, bacterial CSP Salts CSP Methimazole CSP erythroidine CSP halobiphenyl/halotriphenyl compound CSP Selenoprotein P CSP cyclohexane carboxylate CSP Lomustine CSP Shiga Toxins CSP Prodrugs CSP Diuretics CSP Leukotrienes E CSP Proteolipids CSP Thymidine Monophosphate CSP aspidospermine CSP halocarbon compound CSP Mitomycin CSP Abortifacient Agents CSP Morning After Pill CSP Cyclophosphamide CSP Poisons CSP virus envelope
  • 37.NCI Thesaurus NCI Zaditor NCI hydrocortisone acetate NCI KOS-953 NCI Neoral NCI Isotretinoin NCI Spigelia Fluidextract NCI palmitoleic acid NCI Absorbine NCI Monoclonal Antibody N901-bR NCI Coreg Butoxamine HCl NCI Citofolin NCI Amoxil NCI Procyclidine hydrochloride NCI Methylene Chloride NCI SC 48334 NCI Egtazic Acid NCI Valproate NCI CD3-Epsilon-Associated Protein NCI Differentiation Inducer NCI Clonoxifen NCI Myristic Acid NCI piroxantrone NCI Methoxamine NCI Dynacirc NCI Hexa-Germ NCI Trihexyphenidyl Hydrochloride NCI Iodamide NCI CD11b Antigens NCI Abbokinase
  • 38.Clinical Terms V3 RCD Compound salicylic acid powder RCD Expulin RCD Chlorinated phenol disinfectant RCD amyl nitrate RCD Vioform Hydrocortisone RCD Alcuronium RCD methyl isocyanate RCD Lopid RCD Neupogen RCD Shannon stoma adhesive plaster RCD Eolarix vaccine RCD X-porphyrin RCD Deltastab RCD Geref 50 RCD C-Peptide RCD Abidec RCD soldering flux RCD Buspirone RCD cabergoline RCD Dental etching agent RCD E104 RCD Adenoscan RCD Fefol-Vit Spansule RCD Budesonide RCD deteclo RCD Rigid gas permeable contact lens preparations RCD Cannabis substance RCD lypressin RCD Progynova RCD Endorphins RCD Sulparex
  • 39.Metathesaurus SAB CUIStr MTH Nile Blue MTH Manganum sulphuricum, homeopathic preparation MTH Dichlorodiphenyldichloroethane MTH WT2 protein MTH Neuraminic acid MTH Hemoglobin Parchman MTH Evi-1 protein MTH Aesculus hippocastanum, homeopathic preparation MTH sulfur oxide MTH Fiboran MTH Synaptotagmin XII MTH chondrocyte expressed protein-68 MTH Tantalum MTH Prothrombin MTH Albumin |; dialysis fluid peritoneal MTH Tylos Preparation MTH Helicobacter pylori antibody MTH Coccus cacti, Homeopathic preparation MTH Equisetum hyemale, Homeopathic preparation MTH ovocleidin-116 MTH Bupleurum preparation MTH Nux moschata, Homeopathic preparation MTH Ear Drops brand of carbamide peroxide MTH SLC5A5 protein, human MTH Keratin-1 MTH PERILLA preparation MTH Prostaglandins I MTH Phalaris arundinacea antigen MTH Horse Chestnut Preparation
  • 40.Alcohol and Other Drug Thesaurus SAB CUIStr AOD Thrombin AOD Progestins AOD Organic Chemicals AOD Sulfonylurea Compounds AOD Chlorpromazine AOD Phenacetin AOD Metallothionein AOD Anti-Infective Agents, Local AOD R-38486 AOD Apolipoproteins A AOD Beta-glucuronidase AOD Cinchona Alkaloids AOD ethanol metabolite AOD Acyclovir AOD Phosphothreonine AOD Sulfanilamide AOD IgE AOD Captopril AOD compound with nitrogen-nitrogen bond AOD excitatory neurotransmitters AOD Ascheim-Zondek hormone AOD Phenylthiohydantoin AOD Anthramycin AOD Polysaccharides, Bacterial AOD Turpentine AOD Aliphatic unsaturated hydrocarbon AOD Hydromorphone Hydrochloride AOD Neomycin AOD Vitamin K
  • 41.Library of Congress Subject Headings SAB CUIStr LCH Collodion LCH Auxins LCH Mannose LCH Vitamin U LCH Ethylene LCH Nicergoline LCH Platinum LCH Guanidine LCH Indophenol LCH Spironolactone LCH Glycolipids LCH Oxides LCH Amoxicillin LCH Drug vehicle LCH Tetrachlorodibenzodioxin LCH Endosulfan LCH Cyclacillin LCH Etoposide LCH Amidines LCH Veratrine LCH Charcoal LCH Saralasin LCH Aluminum Silicates LCH Aminobutyric Acid LCH Glutamine LCH Amino Alcohols LCH acetamide LCH Theophylline LCH Aerosols
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