Provide one-stop customization service of gene therapy for academic and industrial customers.
2.Nucleic acid services platform
Gene therapy is developing into precise medicines that can manipulate speciﬁc genes in the treatment of serious diseases and vaccines development. To effectively function in vivo, reliable delivery systems are very important to the nucleic acids for protecting them from degradation and allowing effective cellular uptake and release. Based on profound scientiﬁc research accumulation, strong R&D strength and continuous technical support, CD Bioparticles could provide customers with one-stop customization service as:
Nucleic acid services
Delivery systems development
According to the name of the disease or the gene, search the database and literature for the
sequence of the nucleic acid, and select the proper CDS for synthesis.
In Vitro Transcription (IVT)
Chemical synthesis for siRNA, mRNA, DNA, plasmid, ASO, sgRNA, shRNA
The corresponding QC testing services
* Other modiﬁcations if needed.
Cap0/ Cap1/Cap2, Fluorescent Cap, IRES/MS2,
Poly(A) synthesis, UTR modiﬁcation…
m1ψ, m5C, 2'-OMe,
Pseudo-Uridine, LNA, N6 methyladenine, 5 methylcytidune…
3.Delivery system development platforms
Due to the wide range of sources and low immunogenicity, cationic polymers, such as PEI, dendrimers,
chitosan, gelatin are widely used nanoscales delivery systems for gene therapy.
With the similar structure of cell membrane, liposomes are considered to be a safer and more effective delivery system. Its ﬂexibility and robustness in lipid structure, composition, ratio and preparation methods make liposomes an important artiﬁcial carrier for gene therapy. Targeting ligands, such as peptides, antibodies have been successfully applied in liposomes to achieve
active targeting delivery to speciﬁed area. Furthermore, encapsulating ﬂuorescent dyes in liposomes is very beneﬁcial for later tracking and imaging studies.
Lipid nanoparticles (LNPs)
High nucleic acid loading
Stable in vivo
SM-102/MC3/ALC-0315 for research only
Ideal delivery model
LNPs with target groups
Active targeting delivery
4.Delivery system development platforms
Exosomes are nanovesicles derived from cell membrane with natural targeting ability. CD Bioparticles provides various exosome production custom services for gene therapy research.
Viral vectors are a tool commonly used in molecular biology to bring genetic material into cells. The principle is to use the molecular mechanism of viruses to transmit their genomes into other cells for infection. Its high effectiveness and tropism make viral vectors one of the most commonly used carriers for gene therapy. CD Bioparticles could provide a wild range of viral vectors for basic research and preclinical study.
Adenoviral vectors (Ads)
Large packaging capacity
Transduce (non-)dividing cells
High level expression
Lentiviral vectors (LVs)
Retroviral vectors (RVs)
Transduce dividing cells
Adeno-associated viral vectors (AAVs)
High level and long-term